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[R&D] First-in-Human Adjunctive Bacteriophage Therapy for Malakoplakia
2026-08-18

We report the first use of adjunctive bacteriophage therapy for Escherichia coli related malakoplakia in a kidney transplant recipient with progressive disease. 

Adjunctive CRISPR-enhanced phage cocktail SNIPR001 combined with prolonged antibiotics, ascorbic acid, and bethanechol was associated with cutaneous lesion resolution and sustained radiographic regression without phage-related adverse events.


Clin Infect Dis. 2026 Aug 11:ciag446.


https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciag446/8757930?login=true






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