[R&D] First-in-Human Adjunctive Bacteriophage Therapy for Malakoplakia
2026-08-18
We report the first use of adjunctive bacteriophage therapy for Escherichia coli related malakoplakia in a kidney transplant recipient with progressive disease.
Adjunctive CRISPR-enhanced phage cocktail SNIPR001 combined with prolonged antibiotics, ascorbic acid, and bethanechol was associated with cutaneous lesion resolution and sustained radiographic regression without phage-related adverse events.
Clin Infect Dis. 2026 Aug 11:ciag446.
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciag446/8757930?login=true

